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pentobarbital will lessen the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Double brexpiprazole dose over 1-2 months if administered with a robust CYP3A4 inducer.pentobarbital will lessen the extent or effect of ibuprofen by influencing hepatic enzyme CYP2C9/ten metabolis